###Gene summary #Tax_id Org_name GeneID status Symbol Functional_stage Aliases Description Other_designations Map_location Chromosome Genomic_nucleotide_accession Start_pos_on_genomic_acc End_pos_on_genomic_acc Orientation Exon_count OMIM 9606 Homo sapiens 1385 live CREB1 Proliferation CREB, CREB-1 CAMP responsive element binding protein 1,cyclic AMP-responsive element-binding protein 1|active transcription factor CREB|cAMP-response element-binding protein-1|cyclic adenosine 3',5'-monoph 2q33.3 2 NC_000002.12 207529892 207605989 plus 14 123810 ###Disease involvement #GeneID Symbol Category Disease PubMedID Other reference 1385 CREB1 Neurodegenarative disorders Alzheimer's disease 22119240 - 1385 CREB1 Neurodegenarative disorders Parkinson's disease 11739600 - ###RefSeq information #SNo. GeneID Symbol Status RNA_nuc_accver CDPpos Prot_accver Genomic_nuc_accver Start_pos_on_genomic_acc End_pos_on_genomic_acc Orientation Assembly Mature_peptide_accver UniProtKBID PDBID 1 1385 CREB1 MODEL XM_011510645.1 66..1091 XP_011508947.1 NC_000002.12 207529891 207605988 + Reference GRCh3 - Q53X93 2LXT 2 1385 CREB1 MODEL XM_011510646.2 228..1238 XP_011508948.1 NC_000002.12 207529891 207605988 + Reference GRCh3 - Q53X93 2LXT 3 1385 CREB1 MODEL XM_011510647.2 109..1092 XP_011508949.1 NC_000002.12 207529891 207605988 + Reference GRCh3 - Q53X93 2LXT 4 1385 CREB1 MODEL XM_011510648.2 228..1154 XP_011508950.1 NC_000002.12 207529891 207605988 + Reference GRCh3 - Q53X93 2LXT 5 1385 CREB1 MODEL XM_011510649.2 183..1088 XP_011508951.1 NC_000002.12 207529891 207605988 + Reference GRCh3 - Q53X93 2LXT 6 1385 CREB1 MODEL XM_011510650.2 282..1187 XP_011508952.1 NC_000002.12 207529891 207605988 + Reference GRCh3 - Q53X93 2LXT 7 1385 CREB1 MODEL XM_011510651.2 141..1004 XP_011508953.1 NC_000002.12 207529891 207605988 + Reference GRCh3 - Q53X93 2LXT 8 1385 CREB1 MODEL XM_017003399.1 202..1086 XP_016858888.1 NC_000002.12 207529891 207605988 + Reference GRCh3 - Q53X93 2LXT 9 1385 CREB1 MODEL XM_017003400.1 228..1091 XP_016858889.1 NC_000002.12 207529891 207605988 + Reference GRCh3 - Q53X93 2LXT 10 1385 CREB1 MODEL XM_017003401.1 614..949 XP_016858890.1 NC_000002.12 207529891 207605988 + Reference GRCh3 - Q53X93 2LXT 11 1385 CREB1 MODEL XR_001738634.1 - NC_000002.12 207529891 207605988 + Reference GRCh3 - Q53X93 2LXT 12 1385 CREB1 MODEL XR_001738635.1 - NC_000002.12 207529891 207605988 + Reference GRCh3 - Q53X93 2LXT 13 1385 CREB1 MODEL XR_001738636.1 - NC_000002.12 207529891 207605988 + Reference GRCh3 - Q53X93 2LXT 14 1385 CREB1 MODEL XR_001738637.1 - NC_000002.12 207529891 207605988 + Reference GRCh3 - Q53X93 2LXT 15 1385 CREB1 MODEL XR_241290.1 - NC_000002.12 207529891 207605988 + Reference GRCh3 - Q53X93 2LXT 16 1385 CREB1 MODEL XR_241292.1 - NC_000002.12 207529891 207605988 + Reference GRCh3 - Q53X93 2LXT 17 1385 CREB1 REVIEWED - - NG_023299.1 5000 81097 + - - Q53X93 2LXT 18 1385 CREB1 REVIEWED NM_001320793.1 252..956 NP_001307722.1 NC_000002.12 207529891 207605988 + Reference GRCh3 - Q53X93 2LXT 19 1385 CREB1 REVIEWED NM_001320793.1 252..956 NP_001307722.1 NC_018913.2 208400465 208476533 + Alternate CHM1_ - Q53X93 2LXT 20 1385 CREB1 REVIEWED NM_004379.4 252..1235 NP_004370.1 NC_000002.12 207529891 207605988 + Reference GRCh3 - Q53X93 2LXT 21 1385 CREB1 REVIEWED NM_004379.4 252..1235 NP_004370.1 NC_018913.2 208400465 208476533 + Alternate CHM1_ - Q53X93 2LXT 22 1385 CREB1 REVIEWED NM_134442.4 252..1277 NP_604391.1 NC_000002.12 207529891 207605988 + Reference GRCh3 - Q53X93 2LXT 23 1385 CREB1 REVIEWED NM_134442.4 252..1277 NP_604391.1 NC_018913.2 208400465 208476533 + Alternate CHM1_ - Q53X93 2LXT 24 1385 CREB1 REVIEWED NM_134442.4 252..1277 NP_604391.1 NG_023299.1 5000 81097 + - - Q53X93 2LXT 25 1385 CREB1 REVIEWED NR_135473.1 - NC_000002.12 207529891 207605988 + Reference GRCh3 - Q53X93 2LXT 26 1385 CREB1 REVIEWED NR_135473.1 - NC_018913.2 208400465 208476533 + Alternate CHM1_ - Q53X93 2LXT ###Gene Ontology #SNo. TaxonID GeneID GOID Evidence Qualifier GOterm PubMedID Category 1 9606 1385 GO:0000978 IDA - RNA polymerase II core promoter proximal region sequence-specific DNA binding 9065434 Function 2 9606 1385 GO:0000980 IDA - RNA polymerase II distal enhancer sequence-specific DNA binding 19861239 Function 3 9606 1385 GO:0001077 IC - transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specifi 0 Function 4 9606 1385 GO:0001102 IPI - RNA polymerase II activating transcription factor binding 19861239 Function 5 9606 1385 GO:0001190 IDA - transcriptional activator activity, RNA polymerase II transcription factor binding 19861239 Function 6 9606 1385 GO:0001225 IEA - RNA polymerase II transcription coactivator binding 0 Function 7 9606 1385 GO:0001666 IEA - response to hypoxia 0 Process 8 9606 1385 GO:0003700 IDA - transcription factor activity, sequence-specific DNA binding 8798441 Function 9 9606 1385 GO:0003705 IDA - transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding 19861239 Function 10 9606 1385 GO:0003712 TAS - transcription cofactor activity 8552098 Function 11 9606 1385 GO:0005515 IPI - protein binding 10722738 Function 12 9606 1385 GO:0005634 IDA - nucleus 8798441 Component 13 9606 1385 GO:0005654 IDA - nucleoplasm 0 Component 14 9606 1385 GO:0005654 TAS - nucleoplasm 0 Component 15 9606 1385 GO:0005719 IDA - nuclear euchromatin 19861239 Component 16 9606 1385 GO:0005759 IEA - mitochondrial matrix 0 Component 17 9606 1385 GO:0006366 IEA - transcription from RNA polymerase II promoter 0 Process 18 9606 1385 GO:0006468 IDA - protein phosphorylation 8798441 Process 19 9606 1385 GO:0007165 TAS - signal transduction 2974179 Process 20 9606 1385 GO:0007179 IEA - transforming growth factor beta receptor signaling pathway 0 Process 21 9606 1385 GO:0007411 TAS - axon guidance 0 Process 22 9606 1385 GO:0007568 IEA - aging 0 Process 23 9606 1385 GO:0007595 IEA - lactation 0 Process 24 9606 1385 GO:0007613 IEA - memory 0 Process 25 9606 1385 GO:0007623 ISS - circadian rhythm 0 Process 26 9606 1385 GO:0008361 IEA - regulation of cell size 0 Process 27 9606 1385 GO:0008542 IEA - visual learning 0 Process 28 9606 1385 GO:0010033 IDA - response to organic substance 8798441 Process 29 9606 1385 GO:0010944 IDA - negative regulation of transcription by competitive promoter binding 19861239 Process 30 9606 1385 GO:0014823 IEA - response to activity 0 Process 31 9606 1385 GO:0016032 IEA - viral process 0 Process 32 9606 1385 GO:0019899 IPI - enzyme binding 23382074 Function 33 9606 1385 GO:0021983 IEA - pituitary gland development 0 Process 34 9606 1385 GO:0030424 IEA - axon 0 Component 35 9606 1385 GO:0030544 IEA - Hsp70 protein binding 0 Function 36 9606 1385 GO:0032916 IEA - positive regulation of transforming growth factor beta3 production 0 Process 37 9606 1385 GO:0033363 IEA - secretory granule organization 0 Process 38 9606 1385 GO:0033762 ISS - response to glucagon 0 Process 39 9606 1385 GO:0034670 IEA - chemotaxis to arachidonic acid 0 Process 40 9606 1385 GO:0035035 IEA - histone acetyltransferase binding 0 Function 41 9606 1385 GO:0035094 IEA - response to nicotine 0 Process 42 9606 1385 GO:0035497 IDA - cAMP response element binding 19861239 Function 43 9606 1385 GO:0035729 IEA - cellular response to hepatocyte growth factor stimulus 0 Process 44 9606 1385 GO:0036120 IEA - cellular response to platelet-derived growth factor stimulus 0 Process 45 9606 1385 GO:0040018 IEA - positive regulation of multicellular organism growth 0 Process 46 9606 1385 GO:0042493 IEA - response to drug 0 Process 47 9606 1385 GO:0042752 IEA - regulation of circadian rhythm 0 Process 48 9606 1385 GO:0042802 IPI - identical protein binding 20102225 Function 49 9606 1385 GO:0043065 IEA - positive regulation of apoptotic process 0 Process 50 9606 1385 GO:0045600 ISS - positive regulation of fat cell differentiation 0 Process 51 9606 1385 GO:0045672 IEA - positive regulation of osteoclast differentiation 0 Process 52 9606 1385 GO:0045893 ISS - positive regulation of transcription, DNA-templated 0 Process 53 9606 1385 GO:0045899 IEA - positive regulation of RNA polymerase II transcriptional preinitiation complex assembly 0 Process 54 9606 1385 GO:0045944 IDA - positive regulation of transcription from RNA polymerase II promoter 1655749 Process 55 9606 1385 GO:0046887 IEA - positive regulation of hormone secretion 0 Process 56 9606 1385 GO:0046889 ISS - positive regulation of lipid biosynthetic process 0 Process 57 9606 1385 GO:0048145 IEA - regulation of fibroblast proliferation 0 Process 58 9606 1385 GO:0050821 ISS - protein stabilization 0 Process 59 9606 1385 GO:0055025 IEA - positive regulation of cardiac muscle tissue development 0 Process 60 9606 1385 GO:0060251 IEA - regulation of glial cell proliferation 0 Process 61 9606 1385 GO:0060430 IEA - lung saccule development 0 Process 62 9606 1385 GO:0060509 IEA - Type I pneumocyte differentiation 0 Process 63 9606 1385 GO:0071294 IEA - cellular response to zinc ion 0 Process 64 9606 1385 GO:0071398 IEA - cellular response to fatty acid 0 Process 65 9606 1385 GO:1900273 IEA - positive regulation of long-term synaptic potentiation 0 Process 66 9606 1385 GO:1901215 IEA - negative regulation of neuron death 0 Process 67 9606 1385 GO:1902065 IEA - response to L-glutamate 0 Process 68 9606 1385 GO:1990090 IEA - cellular response to nerve growth factor stimulus 0 Process 69 9606 1385 GO:1990314 IEA - cellular response to insulin-like growth factor stimulus 0 Process 70 9606 1385 GO:1990589 IDA - ATF4-CREB1 transcription factor complex 12871976 Component 71 9606 1385 GO:1990763 IEA - arrestin family protein binding 0 Function 72 9606 1385 GO:1990830 IEA - cellular response to leukemia inhibitory factor 0 Process