###Gene summary #Tax_id Org_name GeneID status Symbol Functional_stage Aliases Description Other_designations Map_location Chromosome Genomic_nucleotide_accession Start_pos_on_genomic_acc End_pos_on_genomic_acc Orientation Exon_count OMIM 9606 Homo sapiens 2335 live FN1 Proliferation CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF Fibronectin 1,fibronectin|cold-insoluble globulin|migration-stimulating factor 2q35 2 NC_000002.12 215360440 215436167 minus 47 135600 ###Proliferation functional stage Acute-phase response, angiogenesis, calcium-independent cell-matrix adhesion, cell activation, cell adhesion, cell-matrix adhesion, cell-matrix adhesion, cell-substrate junction assembly, cellular response to interleukin-1, cellular response to mercury ion, endodermal cell differentiation, extracellular matrix organization, glial cell migration, integrin activation, negative regulation of apoptotic process, negative regulation of transforming growth factor-beta secretion, peptide cross-linking, positive regulation of axon extension, positive regulation of cell migration, positive regulation of cell proliferation, positive regulation of chemotaxis, positive regulation of fibroblast proliferation, positive regulation of gene expression ###Disease involvement #GeneID Symbol Category Disease PubMedID Other reference 2335 FN1 Muscular dystrophy Duchenne muscular dystrophy 24458521 - Duchenne muscular dystrophy: Duchenne muscular dystrophy (DMD) is a genetic disorder characterized by progressive muscle degeneration and weakness. It is one of nine types of muscular dystrophy. DMD is caused by an absence of dystrophin, a protein that helps keep muscle cells intact. Symptom onset is in early childhood, usually between ages 3 and 5. The disease primarily affects boys, but in rare cases it can affect girls. ###RefSeq information #SNo. GeneID Symbol Status RNA_nuc_accver CDPpos Prot_accver Genomic_nuc_accver Start_pos_on_genomic_acc End_pos_on_genomic_acc Orientation Assembly Mature_peptide_accver UniProtKBID PDBID 1 2335 FN1 MODEL XM_005246397.1 366..7817 XP_005246454.1 NC_000002.12 215360439 215436166 - Reference GRCh3 - P02751 5DFT 2 2335 FN1 MODEL XM_005246398.1 366..7742 XP_005246455.1 NC_000002.12 215360439 215436166 - Reference GRCh3 - P02751 5DFT 3 2335 FN1 MODEL XM_005246399.1 366..7724 XP_005246456.1 NC_000002.12 215360439 215436166 - Reference GRCh3 - P02751 5DFT 4 2335 FN1 MODEL XM_005246401.1 366..7649 XP_005246458.1 NC_000002.12 215360439 215436166 - Reference GRCh3 - P02751 5DFT 5 2335 FN1 MODEL XM_005246402.1 366..7631 XP_005246459.1 NC_000002.12 215360439 215436166 - Reference GRCh3 - P02751 5DFT 6 2335 FN1 MODEL XM_005246403.1 366..7547 XP_005246460.1 NC_000002.12 215360439 215436166 - Reference GRCh3 - P02751 5DFT 7 2335 FN1 MODEL XM_005246404.1 366..7544 XP_005246461.1 NC_000002.12 215360439 215436166 - Reference GRCh3 - P02751 5DFT 8 2335 FN1 MODEL XM_005246405.1 366..7529 XP_005246462.1 NC_000002.12 215360439 215436166 - Reference GRCh3 - P02751 5DFT 9 2335 FN1 MODEL XM_005246406.1 366..7526 XP_005246463.1 NC_000002.12 215360439 215436166 - Reference GRCh3 - P02751 5DFT 10 2335 FN1 MODEL XM_005246407.1 366..7457 XP_005246464.1 NC_000002.12 215360439 215436166 - Reference GRCh3 - P02751 5DFT 11 2335 FN1 MODEL XM_005246408.1 366..7454 XP_005246465.1 NC_000002.12 215360439 215436166 - Reference GRCh3 - P02751 5DFT 12 2335 FN1 MODEL XM_005246409.1 366..7451 XP_005246466.1 NC_000002.12 215360439 215436166 - Reference GRCh3 - P02751 5DFT 13 2335 FN1 MODEL XM_005246410.1 366..7379 XP_005246467.1 NC_000002.12 215360439 215436166 - Reference GRCh3 - P02751 5DFT 14 2335 FN1 MODEL XM_005246411.1 366..7187 XP_005246468.1 NC_000002.12 215360439 215436166 - Reference GRCh3 - P02751 5DFT 15 2335 FN1 MODEL XM_005246412.1 366..7181 XP_005246469.1 NC_000002.12 215360439 215436166 - Reference GRCh3 - P02751 5DFT 16 2335 FN1 MODEL XM_005246414.1 366..7166 XP_005246471.1 NC_000002.12 215360439 215436166 - Reference GRCh3 - P02751 5DFT 17 2335 FN1 MODEL XM_005246416.1 366..7106 XP_005246473.1 NC_000002.12 215360439 215436166 - Reference GRCh3 - P02751 5DFT 18 2335 FN1 MODEL XM_017003692.1 366..7439 XP_016859181.1 NC_000002.12 215360439 215436166 - Reference GRCh3 - P02751 5DFT 19 2335 FN1 MODEL XM_017003693.1 366..7436 XP_016859182.1 NC_000002.12 215360439 215436166 - Reference GRCh3 - P02751 5DFT 20 2335 FN1 MODEL XM_017003694.1 366..7361 XP_016859183.1 NC_000002.12 215360439 215436166 - Reference GRCh3 - P02751 5DFT 21 2335 FN1 MODEL XM_017003695.1 366..7274 XP_016859184.1 NC_000002.12 215360439 215436166 - Reference GRCh3 - P02751 5DFT 22 2335 FN1 REVIEWED - - NG_012196.1 5000 80628 + - - P02751 5DFT 23 2335 FN1 REVIEWED NM_001306129.1 269..7609 NP_001293058.1 NC_000002.12 215360439 215436166 - Reference GRCh3 - P02751 5DFT 24 2335 FN1 REVIEWED NM_001306129.1 269..7609 NP_001293058.1 NC_018913.2 216231062 216306651 - Alternate CHM1_ - P02751 5DFT 25 2335 FN1 REVIEWED NM_001306130.1 269..7072 NP_001293059.1 NC_000002.12 215360439 215436166 - Reference GRCh3 - P02751 5DFT 26 2335 FN1 REVIEWED NM_001306130.1 269..7072 NP_001293059.1 NC_018913.2 216231062 216306651 - Alternate CHM1_ - P02751 5DFT 27 2335 FN1 REVIEWED NM_001306131.1 269..7066 NP_001293060.1 NC_000002.12 215360439 215436166 - Reference GRCh3 - P02751 5DFT 28 2335 FN1 REVIEWED NM_001306131.1 269..7066 NP_001293060.1 NC_018913.2 216231062 216306651 - Alternate CHM1_ - P02751 5DFT 29 2335 FN1 REVIEWED NM_001306132.1 269..6991 NP_001293061.1 NC_000002.12 215360439 215436166 - Reference GRCh3 - P02751 5DFT 30 2335 FN1 REVIEWED NM_001306132.1 269..6991 NP_001293061.1 NC_018913.2 216231062 216306651 - Alternate CHM1_ - P02751 5DFT 31 2335 FN1 REVIEWED NM_002026.3 267..7334 NP_002017.1 NC_000002.12 215360439 215436166 - Reference GRCh3 - P02751 5DFT 32 2335 FN1 REVIEWED NM_002026.3 267..7334 NP_002017.1 NC_018913.2 216231062 216306651 - Alternate CHM1_ - P02751 5DFT 33 2335 FN1 REVIEWED NM_054034.2 267..2240 NP_473375.2 NC_000002.12 215360439 215436166 - Reference GRCh3 - P02751 5DFT 34 2335 FN1 REVIEWED NM_054034.2 267..2240 NP_473375.2 NC_018913.2 216231062 216306651 - Alternate CHM1_ - P02751 5DFT 35 2335 FN1 REVIEWED NM_212474.2 267..6797 NP_997639.1 NC_000002.12 215360439 215436166 - Reference GRCh3 - P02751 5DFT 36 2335 FN1 REVIEWED NM_212474.2 267..6797 NP_997639.1 NC_018913.2 216231062 216306651 - Alternate CHM1_ - P02751 5DFT 37 2335 FN1 REVIEWED NM_212476.2 267..7157 NP_997641.1 NC_000002.12 215360439 215436166 - Reference GRCh3 - P02751 5DFT 38 2335 FN1 REVIEWED NM_212476.2 267..7157 NP_997641.1 NC_018913.2 216231062 216306651 - Alternate CHM1_ - P02751 5DFT 39 2335 FN1 REVIEWED NM_212478.2 267..7259 NP_997643.1 NC_000002.12 215360439 215436166 - Reference GRCh3 - P02751 5DFT 40 2335 FN1 REVIEWED NM_212478.2 267..7259 NP_997643.1 NC_018913.2 216231062 216306651 - Alternate CHM1_ - P02751 5DFT 41 2335 FN1 REVIEWED NM_212482.2 267..7700 NP_997647.1 NC_000002.12 215360439 215436166 - Reference GRCh3 - P02751 5DFT 42 2335 FN1 REVIEWED NM_212482.2 267..7700 NP_997647.1 NC_018913.2 216231062 216306651 - Alternate CHM1_ - P02751 5DFT 43 2335 FN1 REVIEWED NM_212482.2 267..7700 NP_997647.1 NG_012196.1 5000 80628 + - - P02751 5DFT 44 2335 FN1 SUPPRESSED NM_212475.1 267..7532 - - 0 0 ? - - P02751 5DFT ###Gene Ontology #SNo. TaxonID GeneID GOID Evidence Qualifier GOterm PubMedID Category 1 9606 2335 GO:0001525 IEA - angiogenesis 0 Process 2 9606 2335 GO:0001932 IDA - regulation of protein phosphorylation 11792823 Process 3 9606 2335 GO:0002020 IPI - protease binding 22952693 Function 4 9606 2335 GO:0002576 TAS - platelet degranulation 0 Process 5 9606 2335 GO:0005102 IPI - receptor binding 17849409 Function 6 9606 2335 GO:0005178 IDA - integrin binding 19738201 Function 7 9606 2335 GO:0005178 IMP - integrin binding 24658351 Function 8 9606 2335 GO:0005178 IPI - integrin binding 11792823 Function 9 9606 2335 GO:0005515 IPI - protein binding 1400330 Function 10 9606 2335 GO:0005518 NAS - collagen binding 3024962 Function 11 9606 2335 GO:0005576 IDA - extracellular region 27068509 Component 12 9606 2335 GO:0005576 NAS - extracellular region 14718574 Component 13 9606 2335 GO:0005576 TAS - extracellular region 0 Component 14 9606 2335 GO:0005577 IDA - fibrinogen complex 3997886 Component 15 9606 2335 GO:0005578 IDA - proteinaceous extracellular matrix 26571399 Component 16 9606 2335 GO:0005605 IEA - basal lamina 0 Component 17 9606 2335 GO:0005615 IDA - extracellular space 15292204 Component 18 9606 2335 GO:0005788 TAS - endoplasmic reticulum lumen 0 Component 19 9606 2335 GO:0005793 IDA - endoplasmic reticulum-Golgi intermediate compartment 15308636 Component 20 9606 2335 GO:0006953 IEA - acute-phase response 0 Process 21 9606 2335 GO:0007044 IEA - cell-substrate junction assembly 0 Process 22 9606 2335 GO:0007155 NAS - cell adhesion 1423622 Process 23 9606 2335 GO:0007161 IEA - calcium-independent cell-matrix adhesion 0 Process 24 9606 2335 GO:0008022 IPI - protein C-terminus binding 16677310 Function 25 9606 2335 GO:0008201 NAS - heparin binding 10075919 Function 26 9606 2335 GO:0008284 IDA - positive regulation of cell proliferation 25834989 Process 27 9606 2335 GO:0008360 IEA - regulation of cell shape 0 Process 28 9606 2335 GO:0009611 NAS - response to wounding 7989369 Process 29 9606 2335 GO:0010628 IDA - positive regulation of gene expression 25834989 Process 30 9606 2335 GO:0010952 IEA - positive regulation of peptidase activity 0 Process 31 9606 2335 GO:0016324 IEA - apical plasma membrane 0 Component 32 9606 2335 GO:0016504 IEA - peptidase activator activity 0 Function 33 9606 2335 GO:0018149 IDA - peptide cross-linking 3997886 Process 34 9606 2335 GO:0019899 IPI - enzyme binding 12167537 Function 35 9606 2335 GO:0022617 TAS - extracellular matrix disassembly 0 Process 36 9606 2335 GO:0030198 TAS - extracellular matrix organization 0 Process 37 9606 2335 GO:0031012 IDA - extracellular matrix 1632457 Component 38 9606 2335 GO:0031012 IDA colocalize extracellular matrix 20551380 Component 39 9606 2335 GO:0031012 ISS colocalize extracellular matrix 22261194 Component 40 9606 2335 GO:0031093 TAS - platelet alpha granule lumen 0 Component 41 9606 2335 GO:0033622 IMP - integrin activation 24658351 Process 42 9606 2335 GO:0034446 IDA - substrate adhesion-dependent cell spreading 16236823 Process 43 9606 2335 GO:0034446 IMP - substrate adhesion-dependent cell spreading 24658351 Process 44 9606 2335 GO:0035987 IDA - endodermal cell differentiation 23154389 Process 45 9606 2335 GO:0042060 IEA - wound healing 0 Process 46 9606 2335 GO:0042802 IPI - identical protein binding 17914904 Function 47 9606 2335 GO:0043687 TAS - post-translational protein modification 0 Process 48 9606 2335 GO:0044267 TAS - cellular protein metabolic process 0 Process 49 9606 2335 GO:0045773 IEA - positive regulation of axon extension 0 Process 50 9606 2335 GO:0048146 IDA - positive regulation of fibroblast proliferation 25834989 Process 51 9606 2335 GO:0050900 TAS - leukocyte migration 0 Process 52 9606 2335 GO:0051087 IPI - chaperone binding 17849409 Function 53 9606 2335 GO:0051702 IDA - interaction with symbiont 12167537 Process 54 9606 2335 GO:0052047 IDA - interaction with other organism via secreted substance involved in symbiotic interaction 17849409 Process 55 9606 2335 GO:0070062 IDA - extracellular exosome 19056867 Component 56 9606 2335 GO:0070372 IDA - regulation of ERK1 and ERK2 cascade 11792823 Process 57 9606 2335 GO:0072562 IDA - blood microparticle 22516433 Component 58 9606 2335 GO:0097718 IPI - disordered domain specific binding 15292204 Function 59 9606 2335 GO:1904237 IDA - positive regulation of substrate-dependent cell migration, cell attachment to substrate 25834989 Process 60 9606 2335 GO:2001202 IDA - negative regulation of transforming growth factor-beta secretion 25834989 Process