###Gene summary #Tax_id Org_name GeneID status Symbol Functional_stage Aliases Description Other_designations Map_location Chromosome Genomic_nucleotide_accession Start_pos_on_genomic_acc End_pos_on_genomic_acc Orientation Exon_count OMIM 9606 Homo sapiens 3480 live IGF1R Proliferation CD221, IGFIR, IGFR, JTK13 Insulin like growth factor 1 receptor,insulin-like growth factor 1 receptor|IGF-I receptor|soluble IGF1R variant 1|soluble IGF1R variant 2 15q26.3 15 NC_000015.10 98648539 98964530 plus 25 147370 ###Proliferation functional stage Negative regulation of muscle cell apoptotic process, positive regulation of osteoblast proliferation, positive regulation of smooth muscle cell proliferation ###RefSeq information #SNo. GeneID Symbol Status RNA_nuc_accver CDPpos Prot_accver Genomic_nuc_accver Start_pos_on_genomic_acc End_pos_on_genomic_acc Orientation Assembly Mature_peptide_accver UniProtKBID PDBID 1 3480 IGF1R MODEL XM_011521516.2 403..3597 XP_011519818.1 NC_000015.10 98648538 98964529 + Reference GRCh3 - P08069 4D2R 2 3480 IGF1R MODEL XM_011521517.2 242..3010 XP_011519819.1 NC_000015.10 98648538 98964529 + Reference GRCh3 - P08069 4D2R 3 3480 IGF1R MODEL XM_017022136.1 472..4650 XP_016877625.1 NC_000015.10 98648538 98964529 + Reference GRCh3 - P08069 4D2R 4 3480 IGF1R MODEL XM_017022137.1 472..4650 XP_016877626.1 NC_000015.10 98648538 98964529 + Reference GRCh3 - P08069 4D2R 5 3480 IGF1R MODEL XM_017022138.1 472..4647 XP_016877627.1 NC_000015.10 98648538 98964529 + Reference GRCh3 - P08069 4D2R 6 3480 IGF1R MODEL XM_017022139.1 348..4088 XP_016877628.1 NC_000015.10 98648538 98964529 + Reference GRCh3 - P08069 4D2R 7 3480 IGF1R REVIEWED - - NG_009492.1 4007 319998 + - - P08069 4D2R 8 3480 IGF1R REVIEWED NM_000875.4 1044..5147 NP_000866.1 NC_000015.10 98648538 98964529 + Reference GRCh3 - P08069 4D2R 9 3480 IGF1R REVIEWED NM_000875.4 1044..5147 NP_000866.1 NC_018926.2 99033295 99349170 + Alternate CHM1_ - P08069 4D2R 10 3480 IGF1R REVIEWED NM_000875.4 1044..5147 NP_000866.1 NG_009492.1 4007 319998 + - - P08069 4D2R 11 3480 IGF1R REVIEWED NM_001291858.1 1044..5144 NP_001278787.1 NC_000015.10 98648538 98964529 + Reference GRCh3 - P08069 4D2R 12 3480 IGF1R REVIEWED NM_001291858.1 1044..5144 NP_001278787.1 NC_018926.2 99033295 99349170 + Alternate CHM1_ - P08069 4D2R 13 3480 IGF1R REVIEWED NM_001291858.1 1044..5144 NP_001278787.1 NG_009492.1 4007 319998 + - - P08069 4D2R 14 3480 IGF1R SUPPRESSED NM_152452.1 2207..2374 - - 0 0 ? - - P08069 4D2R ###Gene Ontology #SNo. TaxonID GeneID GOID Evidence Qualifier GOterm PubMedID Category 1 9606 3480 GO:0004713 IDA - protein tyrosine kinase activity 7679099 Function 2 9606 3480 GO:0004713 IMP - protein tyrosine kinase activity 11884589 Function 3 9606 3480 GO:0004713 TAS - protein tyrosine kinase activity 0 Function 4 9606 3480 GO:0005010 IDA - insulin-like growth factor-activated receptor activity 7679099 Function 5 9606 3480 GO:0005158 IDA - insulin receptor binding 8452530 Function 6 9606 3480 GO:0005515 IPI - protein binding 7541045 Function 7 9606 3480 GO:0005520 IDA - insulin-like growth factor binding 1846292 Function 8 9606 3480 GO:0005524 IEA - ATP binding 0 Function 9 9606 3480 GO:0005886 ISS - plasma membrane 0 Component 10 9606 3480 GO:0005886 TAS - plasma membrane 0 Component 11 9606 3480 GO:0005887 IC - integral component of plasma membrane 7679099 Component 12 9606 3480 GO:0006955 IMP - immune response 16886151 Process 13 9606 3480 GO:0007165 TAS - signal transduction 3003744 Process 14 9606 3480 GO:0008284 TAS - positive regulation of cell proliferation 10749889 Process 15 9606 3480 GO:0008286 ISS - insulin receptor signaling pathway 19406747 Process 16 9606 3480 GO:0014065 IC - phosphatidylinositol 3-kinase signaling 7541045 Process 17 9606 3480 GO:0016020 IDA - membrane 8452530 Component 18 9606 3480 GO:0030335 IMP - positive regulation of cell migration 12138094 Process 19 9606 3480 GO:0031994 IDA - insulin-like growth factor I binding 19578119 Function 20 9606 3480 GO:0031994 IPI - insulin-like growth factor I binding 8452530 Function 21 9606 3480 GO:0035867 IDA - alphav-beta3 integrin-IGF-1-IGF1R complex 19578119 Component 22 9606 3480 GO:0038083 IMP - peptidyl-tyrosine autophosphorylation 19545541 Process 23 9606 3480 GO:0042802 IPI - identical protein binding 11448933 Function 24 9606 3480 GO:0043066 IDA - negative regulation of apoptotic process 12556535 Process 25 9606 3480 GO:0043231 IDA - intracellular membrane-bounded organelle 8452530 Component 26 9606 3480 GO:0043235 IDA - receptor complex 23382219 Component 27 9606 3480 GO:0043243 ISS - positive regulation of protein complex disassembly 19406747 Process 28 9606 3480 GO:0043548 IPI - phosphatidylinositol 3-kinase binding 7541045 Function 29 9606 3480 GO:0043559 IPI - insulin binding 8452530 Function 30 9606 3480 GO:0043560 IPI - insulin receptor substrate binding 7541045 Function 31 9606 3480 GO:0045740 IMP - positive regulation of DNA replication 12138094 Process 32 9606 3480 GO:0046328 IDA - regulation of JNK cascade 12556535 Process 33 9606 3480 GO:0046777 IDA - protein autophosphorylation 1846292 Process 34 9606 3480 GO:0048009 IDA - insulin-like growth factor receptor signaling pathway 7679099 Process 35 9606 3480 GO:0048015 IDA - phosphatidylinositol-mediated signaling 7692086 Process 36 9606 3480 GO:0051262 IDA - protein tetramerization 1846292 Process 37 9606 3480 GO:0051389 IDA - inactivation of MAPKK activity 12556535 Process 38 9606 3480 GO:0097062 ISS - dendritic spine maintenance 19406747 Process 39 9606 3480 GO:0097242 IMP - amyloid-beta clearance 19406747 Process 40 9606 3480 GO:1904646 IGI - cellular response to amyloid-beta 22635104 Process