###Gene summary #Tax_id Org_name GeneID status Symbol Functional_stage Aliases Description Other_designations Map_location Chromosome Genomic_nucleotide_accession Start_pos_on_genomic_acc End_pos_on_genomic_acc Orientation Exon_count OMIM 9606 Homo sapiens 3976 live LIF Proliferation CDF, DIA, HILDA, MLPLI LIF, interleukin 6 family cytokine,leukemia inhibitory factor|D factor|cholinergic differentiation factor|differentiation inhibitory activity|differentiation-inducing factor|differentia 22q12.2 22 NC_000022.11 30240447 30246851 minus 3 159540 ###Disease involvement #GeneID Symbol Category Disease PubMedID Other reference 3976 LIF Neurodegenarative disorders Alzheimer's disease and Parkinson's disease 20074285 - ###RefSeq information #SNo. GeneID Symbol Status RNA_nuc_accver CDPpos Prot_accver Genomic_nuc_accver Start_pos_on_genomic_acc End_pos_on_genomic_acc Orientation Assembly Mature_peptide_accver UniProtKBID PDBID 1 3976 LIF REVIEWED - - NG_008721.1 4956 11360 + - - P15018 2Q7N 2 3976 LIF REVIEWED NM_001257135.1 157..423 NP_001244064.1 NC_000022.11 30240446 30246850 - Reference GRCh3 - P15018 2Q7N 3 3976 LIF REVIEWED NM_001257135.1 157..423 NP_001244064.1 NC_018933.2 30595572 30601976 - Alternate CHM1_ - P15018 2Q7N 4 3976 LIF REVIEWED NM_002309.4 157..765 NP_002300.1 NC_000022.11 30240446 30246850 - Reference GRCh3 - P15018 2Q7N 5 3976 LIF REVIEWED NM_002309.4 157..765 NP_002300.1 NC_018933.2 30595572 30601976 - Alternate CHM1_ - P15018 2Q7N 6 3976 LIF REVIEWED NM_002309.4 157..765 NP_002300.1 NG_008721.1 4956 11360 + - - P15018 2Q7N ###Gene Ontology #SNo. TaxonID GeneID GOID Evidence Qualifier GOterm PubMedID Category 1 9606 3976 GO:0001135 IDA - transcription factor activity, RNA polymerase II transcription factor recruiting 22783022 Function 2 9606 3976 GO:0001974 IEA - blood vessel remodeling 0 Process 3 9606 3976 GO:0005102 IPI - receptor binding 8999038 Function 4 9606 3976 GO:0005125 IDA - cytokine activity 7957045 Function 5 9606 3976 GO:0005146 IDA - leukemia inhibitory factor receptor binding 7957045 Function 6 9606 3976 GO:0005146 IPI - leukemia inhibitory factor receptor binding 8999038 Function 7 9606 3976 GO:0005515 IPI - protein binding 14527405 Function 8 9606 3976 GO:0005576 TAS - extracellular region 0 Component 9 9606 3976 GO:0005615 IC - extracellular space 12643274 Component 10 9606 3976 GO:0005829 IDA - cytosol 0 Component 11 9606 3976 GO:0006955 IEA - immune response 0 Process 12 9606 3976 GO:0007260 IEA - tyrosine phosphorylation of STAT protein 0 Process 13 9606 3976 GO:0007275 TAS - multicellular organism development 3143918 Process 14 9606 3976 GO:0007566 IEA - embryo implantation 0 Process 15 9606 3976 GO:0008083 IDA - growth factor activity 7957045 Function 16 9606 3976 GO:0008284 IDA - positive regulation of cell proliferation 7957045 Process 17 9606 3976 GO:0008285 IEA - negative regulation of cell proliferation 0 Process 18 9606 3976 GO:0010469 IEA - regulation of receptor activity 0 Process 19 9606 3976 GO:0019827 IEA - stem cell population maintenance 0 Process 20 9606 3976 GO:0033138 IDA - positive regulation of peptidyl-serine phosphorylation 7508917 Process 21 9606 3976 GO:0033141 IDA - positive regulation of peptidyl-serine phosphorylation of STAT protein 20624457 Process 22 9606 3976 GO:0042531 IDA - positive regulation of tyrosine phosphorylation of STAT protein 20624457 Process 23 9606 3976 GO:0043410 IDA - positive regulation of MAPK cascade 7508917 Process 24 9606 3976 GO:0045651 IDA - positive regulation of macrophage differentiation 7957045 Process 25 9606 3976 GO:0045835 IEA - negative regulation of meiotic nuclear division 0 Process 26 9606 3976 GO:0045944 IDA - positive regulation of transcription from RNA polymerase II promoter 7508917 Process 27 9606 3976 GO:0046697 IEA - decidualization 0 Process 28 9606 3976 GO:0046888 IDA - negative regulation of hormone secretion 7867561 Process 29 9606 3976 GO:0048286 IEA - lung alveolus development 0 Process 30 9606 3976 GO:0048644 IEA - muscle organ morphogenesis 0 Process 31 9606 3976 GO:0048666 IEA - neuron development 0 Process 32 9606 3976 GO:0048711 IEA - positive regulation of astrocyte differentiation 0 Process 33 9606 3976 GO:0048861 IDA - leukemia inhibitory factor signaling pathway 8999038 Process 34 9606 3976 GO:0048863 IEA - stem cell differentiation 0 Process 35 9606 3976 GO:0050731 IDA - positive regulation of peptidyl-tyrosine phosphorylation 7508917 Process 36 9606 3976 GO:0060426 IEA - lung vasculature development 0 Process 37 9606 3976 GO:0060463 IEA - lung lobe morphogenesis 0 Process 38 9606 3976 GO:0060707 IEA - trophoblast giant cell differentiation 0 Process 39 9606 3976 GO:0060708 IEA - spongiotrophoblast differentiation 0 Process 40 9606 3976 GO:0070373 IEA - negative regulation of ERK1 and ERK2 cascade 0 Process 41 9606 3976 GO:0072108 IDA - positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis 20624457 Process 42 9606 3976 GO:0072307 IDA - regulation of metanephric nephron tubule epithelial cell differentiation 20624457 Process 43 9606 3976 GO:1900182 IDA - positive regulation of protein localization to nucleus 22783022 Process 44 9606 3976 GO:1901676 IDA - positive regulation of histone H3-K27 acetylation 22783022 Process 45 9606 3976 GO:1903025 IEA - regulation of RNA polymerase II regulatory region sequence-specific DNA binding 0 Process