###Gene summary #Tax_id Org_name GeneID status Symbol Functional_stage Aliases Description Other_designations Map_location Chromosome Genomic_nucleotide_accession Start_pos_on_genomic_acc End_pos_on_genomic_acc Orientation Exon_count OMIM 9606 Homo sapiens 5594 live MAPK1 Proliferation ERK, ERK-2, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p Mitogen-activated protein kinase 1,mitogen-activated protein kinase 1|MAP kinase 1|MAP kinase 2|MAP kinase isoform p42|MAPK 2|extracellular signal-regulated kinase 2|mitogen-activated p 22q11.22 22 NC_000022.11 21759657 21867680 minus 9 176948 ###Disease involvement #GeneID Symbol Category Disease PubMedID Other reference 5594 MAPK1 Neurodegenarative disorders Parkinson's disease 28365714 - 5594 MAPK1 Neurodegenarative disorders Alzheimer's disease 12566928 - ###RefSeq information #SNo. GeneID Symbol Status RNA_nuc_accver CDPpos Prot_accver Genomic_nuc_accver Start_pos_on_genomic_acc End_pos_on_genomic_acc Orientation Assembly Mature_peptide_accver UniProtKBID PDBID 1 5594 MAPK1 REVIEWED - - NG_023054.2 5000 113023 + - - Q1HBJ4 5BUJ 2 5594 MAPK1 REVIEWED NM_002745.4 241..1323 NP_002736.3 NC_000022.11 21759656 21867679 - Reference GRCh3 - Q1HBJ4 5BUJ 3 5594 MAPK1 REVIEWED NM_002745.4 241..1323 NP_002736.3 NC_018933.2 22114126 22222149 - Alternate CHM1_ - Q1HBJ4 5BUJ 4 5594 MAPK1 REVIEWED NM_002745.4 241..1323 NP_002736.3 NG_023054.2 5000 113023 + - - Q1HBJ4 5BUJ 5 5594 MAPK1 REVIEWED NM_138957.3 241..1323 NP_620407.1 NC_000022.11 21759656 21867679 - Reference GRCh3 - Q1HBJ4 5BUJ 6 5594 MAPK1 REVIEWED NM_138957.3 241..1323 NP_620407.1 NC_018933.2 22114126 22222149 - Alternate CHM1_ - Q1HBJ4 5BUJ 7 5594 MAPK1 REVIEWED NM_138957.3 241..1323 NP_620407.1 NG_023054.2 5000 113023 + - - Q1HBJ4 5BUJ ###Gene Ontology #SNo. TaxonID GeneID GOID Evidence Qualifier GOterm PubMedID Category 1 9606 5594 GO:0000165 TAS - MAPK cascade 0 Process 2 9606 5594 GO:0000187 TAS - activation of MAPK activity 0 Process 3 9606 5594 GO:0001784 IEA - phosphotyrosine residue binding 0 Function 4 9606 5594 GO:0003677 IEA - DNA binding 0 Function 5 9606 5594 GO:0004674 IDA - protein serine/threonine kinase activity 15850461 Function 6 9606 5594 GO:0004674 TAS - protein serine/threonine kinase activity 0 Function 7 9606 5594 GO:0004707 IBA - MAP kinase activity 0 Function 8 9606 5594 GO:0004707 TAS - MAP kinase activity 0 Function 9 9606 5594 GO:0004708 IEA - MAP kinase kinase activity 0 Function 10 9606 5594 GO:0005515 IPI - protein binding 8626452 Function 11 9606 5594 GO:0005524 IEA - ATP binding 0 Function 12 9606 5594 GO:0005576 TAS - extracellular region 0 Component 13 9606 5594 GO:0005634 IDA - nucleus 16791210 Component 14 9606 5594 GO:0005634 TAS - nucleus 19565474 Component 15 9606 5594 GO:0005654 TAS - nucleoplasm 0 Component 16 9606 5594 GO:0005737 IDA - cytoplasm 16791210 Component 17 9606 5594 GO:0005737 ISS - cytoplasm 0 Component 18 9606 5594 GO:0005739 TAS - mitochondrion 19565474 Component 19 9606 5594 GO:0005769 TAS - early endosome 19565474 Component 20 9606 5594 GO:0005770 TAS - late endosome 19565474 Component 21 9606 5594 GO:0005794 TAS - Golgi apparatus 19565474 Component 22 9606 5594 GO:0005815 IEA - microtubule organizing center 0 Component 23 9606 5594 GO:0005829 TAS - cytosol 19565474 Component 24 9606 5594 GO:0005856 TAS - cytoskeleton 19565474 Component 25 9606 5594 GO:0005886 ISS - plasma membrane 0 Component 26 9606 5594 GO:0005901 ISS - caveola 0 Component 27 9606 5594 GO:0005901 TAS - caveola 19565474 Component 28 9606 5594 GO:0005925 TAS - focal adhesion 19565474 Component 29 9606 5594 GO:0006351 IEA - transcription, DNA-templated 0 Process 30 9606 5594 GO:0006468 IDA - protein phosphorylation 23184662 Process 31 9606 5594 GO:0006468 TAS - protein phosphorylation 11404397 Process 32 9606 5594 GO:0006915 IEA - apoptotic process 0 Process 33 9606 5594 GO:0006935 TAS - chemotaxis 10706854 Process 34 9606 5594 GO:0006950 TAS - response to stress 10958679 Process 35 9606 5594 GO:0006974 IEA - cellular response to DNA damage stimulus 0 Process 36 9606 5594 GO:0007049 IEA - cell cycle 0 Process 37 9606 5594 GO:0007165 TAS - signal transduction 1540184 Process 38 9606 5594 GO:0007268 TAS - chemical synaptic transmission 10051431 Process 39 9606 5594 GO:0007411 TAS - axon guidance 0 Process 40 9606 5594 GO:0007611 NAS - learning or memory 11404397 Process 41 9606 5594 GO:0008134 IEA - transcription factor binding 0 Function 42 9606 5594 GO:0008284 IEA - positive regulation of cell proliferation 0 Process 43 9606 5594 GO:0008353 ISS - RNA polymerase II carboxy-terminal domain kinase activity 0 Function 44 9606 5594 GO:0008543 TAS - fibroblast growth factor receptor signaling pathway 0 Process 45 9606 5594 GO:0009636 IEA - response to toxic substance 0 Process 46 9606 5594 GO:0010628 IMP - positive regulation of gene expression 24136195 Process 47 9606 5594 GO:0010800 IDA - positive regulation of peptidyl-threonine phosphorylation 16314496 Process 48 9606 5594 GO:0014066 TAS - regulation of phosphatidylinositol 3-kinase signaling 0 Process 49 9606 5594 GO:0015966 IEA - diadenosine tetraphosphate biosynthetic process 0 Process 50 9606 5594 GO:0016032 IEA - viral process 0 Process 51 9606 5594 GO:0016301 TAS - kinase activity 0 Function 52 9606 5594 GO:0018105 IDA - peptidyl-serine phosphorylation 15850461 Process 53 9606 5594 GO:0018107 ISS - peptidyl-threonine phosphorylation 0 Process 54 9606 5594 GO:0019233 IEA - sensory perception of pain 0 Process 55 9606 5594 GO:0019858 IEA - cytosine metabolic process 0 Process 56 9606 5594 GO:0019902 IPI - phosphatase binding 19494114 Function 57 9606 5594 GO:0030168 TAS - platelet activation 0 Process 58 9606 5594 GO:0030278 IEA - regulation of ossification 0 Process 59 9606 5594 GO:0030335 IEA - positive regulation of cell migration 0 Process 60 9606 5594 GO:0030424 IEA - axon 0 Component 61 9606 5594 GO:0030641 IEA - regulation of cellular pH 0 Process 62 9606 5594 GO:0030878 IEA - thyroid gland development 0 Process 63 9606 5594 GO:0031143 IEA - pseudopodium 0 Component 64 9606 5594 GO:0031435 IEA - mitogen-activated protein kinase kinase kinase binding 0 Function 65 9606 5594 GO:0031647 ISS - regulation of protein stability 0 Process 66 9606 5594 GO:0031663 IEA - lipopolysaccharide-mediated signaling pathway 0 Process 67 9606 5594 GO:0032212 IMP - positive regulation of telomere maintenance via telomerase 21531765 Process 68 9606 5594 GO:0032839 IEA - dendrite cytoplasm 0 Component 69 9606 5594 GO:0032872 TAS - regulation of stress-activated MAPK cascade 19565474 Process 70 9606 5594 GO:0033160 IEA - positive regulation of protein import into nucleus, translocation 0 Process 71 9606 5594 GO:0033598 IEA - mammary gland epithelial cell proliferation 0 Process 72 9606 5594 GO:0034198 IDA - cellular response to amino acid starvation 11096076 Process 73 9606 5594 GO:0034614 IMP - cellular response to reactive oxygen species 26514923 Process 74 9606 5594 GO:0035094 ISS - response to nicotine 0 Process 75 9606 5594 GO:0035578 TAS - azurophil granule lumen 0 Component 76 9606 5594 GO:0038095 TAS - Fc-epsilon receptor signaling pathway 0 Process 77 9606 5594 GO:0038096 TAS - Fc-gamma receptor signaling pathway involved in phagocytosis 0 Process 78 9606 5594 GO:0038127 IDA - ERBB signaling pathway 15133037 Process 79 9606 5594 GO:0042473 IEA - outer ear morphogenesis 0 Process 80 9606 5594 GO:0042802 IPI - identical protein binding 16627622 Function 81 9606 5594 GO:0043204 IEA - perikaryon 0 Component 82 9606 5594 GO:0043234 IEA - protein complex 0 Component 83 9606 5594 GO:0043312 TAS - neutrophil degranulation 0 Process 84 9606 5594 GO:0043330 IEA - response to exogenous dsRNA 0 Process 85 9606 5594 GO:0043627 IEA - response to estrogen 0 Process 86 9606 5594 GO:0045596 IEA - negative regulation of cell differentiation 0 Process 87 9606 5594 GO:0045727 IEA - positive regulation of translation 0 Process 88 9606 5594 GO:0045893 IEA - positive regulation of transcription, DNA-templated 0 Process 89 9606 5594 GO:0048538 IEA - thymus development 0 Process 90 9606 5594 GO:0050852 IEA - T cell receptor signaling pathway 0 Process 91 9606 5594 GO:0050853 IEA - B cell receptor signaling pathway 0 Process 92 9606 5594 GO:0051090 TAS - regulation of sequence-specific DNA binding transcription factor activity 0 Process 93 9606 5594 GO:0051403 IDA - stress-activated MAPK cascade 11096076 Process 94 9606 5594 GO:0051493 TAS - regulation of cytoskeleton organization 19565474 Process 95 9606 5594 GO:0051973 IMP - positive regulation of telomerase activity 21531765 Process 96 9606 5594 GO:0060020 IEA - Bergmann glial cell differentiation 0 Process 97 9606 5594 GO:0060291 IEA - long-term synaptic potentiation 0 Process 98 9606 5594 GO:0060324 IEA - face development 0 Process 99 9606 5594 GO:0060397 TAS - JAK-STAT cascade involved in growth hormone signaling pathway 0 Process 100 9606 5594 GO:0060425 IEA - lung morphogenesis 0 Process 101 9606 5594 GO:0060440 IEA - trachea formation 0 Process 102 9606 5594 GO:0060716 IEA - labyrinthine layer blood vessel development 0 Process 103 9606 5594 GO:0061308 IEA - cardiac neural crest cell development involved in heart development 0 Process 104 9606 5594 GO:0070062 IDA - extracellular exosome 23376485 Component 105 9606 5594 GO:0070371 IDA - ERK1 and ERK2 cascade 16314496 Process 106 9606 5594 GO:0070371 TAS - ERK1 and ERK2 cascade 0 Process 107 9606 5594 GO:0070849 IDA - response to epidermal growth factor 18794356 Process 108 9606 5594 GO:0071276 IMP - cellular response to cadmium ion 26514923 Process 109 9606 5594 GO:0072584 TAS - caveolin-mediated endocytosis 19565474 Process 110 9606 5594 GO:0072686 ISS - mitotic spindle 0 Component 111 9606 5594 GO:0090170 TAS - regulation of Golgi inheritance 19565474 Process 112 9606 5594 GO:0097011 IEA - cellular response to granulocyte macrophage colony-stimulating factor stimulus 0 Process 113 9606 5594 GO:1900034 TAS - regulation of cellular response to heat 0 Process 114 9606 5594 GO:1903351 IMP - cellular response to dopamine 24136195 Process 115 9606 5594 GO:1904355 IMP - positive regulation of telomere capping 21531765 Process 116 9606 5594 GO:1904813 TAS - ficolin-1-rich granule lumen 0 Component 117 9606 5594 GO:2000641 TAS - regulation of early endosome to late endosome transport 19565474 Process